Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation.
Identifieur interne : 000120 ( Main/Exploration ); précédent : 000119; suivant : 000121Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation.
Auteurs : Eva Unternaehrer [Canada] ; Margarete Bolten [Allemagne] ; Irina Nast [Suisse] ; Simon Staehli [Allemagne] ; Andrea H. Meyer [Suisse] ; Emma Dempster [Royaume-Uni] ; Dirk H. Hellhammer [Allemagne] ; Roselind Lieb [Suisse] ; Gunther Meinlschmidt [Suisse]Source :
- Social cognitive and affective neuroscience [ 1749-5024 ] ; 2016.
Abstract
The aim of this study was to investigate whether maternal adversities and cortisol levels during pregnancy predict cord blood DNA methylation of the oxytocin receptor (OXTR). We collected cord blood of 39 babies born to mothers participating in a cross-sectional study (N = 100) conducted in Basel, Switzerland (2007-10). Mothers completed the Inventory of Life Events (second trimester: T2), the Edinburgh Postnatal Depression Scale (EPDS, third trimester: T3), the Trier Inventory of Chronic Stress (TICS-K, 1-3 weeks postpartum) and provided saliva samples (T2, T3) for maternal cortisol profiles, as computed by the area under the curve with respect to ground (AUCg) or increase (AUCi) for the cortisol awakening response (CAR) and for diurnal cortisol profiles (DAY). OXTR DNA methylation was quantified using Sequenom EpiTYPER. The number of stressful life events (P = 0.032), EPDS score (P = 0.007) and cortisol AUCgs at T2 (CAR: P = 0.020; DAY: P = 0.024) were negatively associated with OXTR DNA methylation. Our findings suggest that distinct prenatal adversities predict decreased DNA methylation in a gene that is relevant for childbirth, maternal behavior and wellbeing of mother and offspring. If a reduced OXTR methylation increases OXTR expression, our findings could suggest an epigenetic adaptation to an adverse early environment.
DOI: 10.1093/scan/nsw051
PubMed: 27107296
Affiliations:
- Allemagne, Canada, Royaume-Uni, Suisse
- Bavière, District de Haute-Bavière, Rhénanie-Palatinat
- Munich, Trèves (Allemagne)
- Université de Trèves
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000097
- to stream PubMed, to step Curation: 000097
- to stream PubMed, to step Checkpoint: 000097
- to stream Ncbi, to step Merge: 000925
- to stream Ncbi, to step Curation: 000925
- to stream Ncbi, to step Checkpoint: 000925
- to stream Main, to step Merge: 000120
- to stream Main, to step Curation: 000120
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation.</title><author><name sortKey="Unternaehrer, Eva" sort="Unternaehrer, Eva" uniqKey="Unternaehrer E" first="Eva" last="Unternaehrer">Eva Unternaehrer</name><affiliation wicri:level="1"><nlm:affiliation>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Douglas Mental Health University Institute, McGill University, 6875 La Salle Boulevard, Montreal, QC H4H 1R3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Douglas Mental Health University Institute, McGill University, 6875 La Salle Boulevard, Montreal, QC H4H 1R3</wicri:regionArea><wicri:noRegion>QC H4H 1R3</wicri:noRegion></affiliation></author><author><name sortKey="Bolten, Margarete" sort="Bolten, Margarete" uniqKey="Bolten M" first="Margarete" last="Bolten">Margarete Bolten</name><affiliation wicri:level="3"><nlm:affiliation>University of Basel, Child and Adolescent Psychiatric Hospital, 4058 Basel, Switzerland Ludwig-Maximilians-University Munich, Department of Psychology, 80802 Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Basel, Child and Adolescent Psychiatric Hospital, 4058 Basel, Switzerland Ludwig-Maximilians-University Munich, Department of Psychology, 80802 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Nast, Irina" sort="Nast, Irina" uniqKey="Nast I" first="Irina" last="Nast">Irina Nast</name><affiliation wicri:level="1"><nlm:affiliation>University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Zurich University of Applied Sciences, School of Health Professions, 8401 Winterthur, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Zurich University of Applied Sciences, School of Health Professions, 8401 Winterthur</wicri:regionArea><wicri:noRegion>8401 Winterthur</wicri:noRegion></affiliation></author><author><name sortKey="Staehli, Simon" sort="Staehli, Simon" uniqKey="Staehli S" first="Simon" last="Staehli">Simon Staehli</name><affiliation wicri:level="4"><nlm:affiliation>University of Trier, Institute of Psychobiology, 54296 Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Trier, Institute of Psychobiology, 54296 Trier</wicri:regionArea><wicri:noRegion>54296 Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Meyer, Andrea H" sort="Meyer, Andrea H" uniqKey="Meyer A" first="Andrea H" last="Meyer">Andrea H. Meyer</name><affiliation wicri:level="1"><nlm:affiliation>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel</wicri:regionArea><wicri:noRegion>4055 Basel</wicri:noRegion></affiliation></author><author><name sortKey="Dempster, Emma" sort="Dempster, Emma" uniqKey="Dempster E" first="Emma" last="Dempster">Emma Dempster</name><affiliation wicri:level="1"><nlm:affiliation>University of Exeter Medical School, Exeter EX1 2LU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Exeter Medical School, Exeter EX1 2LU</wicri:regionArea><wicri:noRegion>Exeter EX1 2LU</wicri:noRegion></affiliation></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Stress Medicine Trier, 54295 Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stress Medicine Trier, 54295 Trier</wicri:regionArea><wicri:noRegion>54295 Trier</wicri:noRegion><wicri:noRegion>54295 Trier</wicri:noRegion><wicri:noRegion>54295 Trier</wicri:noRegion></affiliation></author><author><name sortKey="Lieb, Roselind" sort="Lieb, Roselind" uniqKey="Lieb R" first="Roselind" last="Lieb">Roselind Lieb</name><affiliation wicri:level="1"><nlm:affiliation>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel</wicri:regionArea><wicri:noRegion>4055 Basel</wicri:noRegion></affiliation></author><author><name sortKey="Meinlschmidt, Gunther" sort="Meinlschmidt, Gunther" uniqKey="Meinlschmidt G" first="Gunther" last="Meinlschmidt">Gunther Meinlschmidt</name><affiliation wicri:level="1"><nlm:affiliation>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Ruhr-University Bochum, Faculty of Medicine, Universitaetsstrasse 150, 44801 Bochum, Germany gunther.meinlschmidt@unibas.ch.</nlm:affiliation><country wicri:rule="url">Suisse</country><wicri:regionArea>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Ruhr-University Bochum, Faculty of Medicine, Universitaetsstrasse 150, 44801 Bochum</wicri:regionArea><wicri:noRegion>44801 Bochum</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27107296</idno><idno type="pmid">27107296</idno><idno type="doi">10.1093/scan/nsw051</idno><idno type="wicri:Area/PubMed/Corpus">000097</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000097</idno><idno type="wicri:Area/PubMed/Curation">000097</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000097</idno><idno type="wicri:Area/PubMed/Checkpoint">000097</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000097</idno><idno type="wicri:Area/Ncbi/Merge">000925</idno><idno type="wicri:Area/Ncbi/Curation">000925</idno><idno type="wicri:Area/Ncbi/Checkpoint">000925</idno><idno type="wicri:Area/Main/Merge">000120</idno><idno type="wicri:Area/Main/Curation">000120</idno><idno type="wicri:Area/Main/Exploration">000120</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation.</title><author><name sortKey="Unternaehrer, Eva" sort="Unternaehrer, Eva" uniqKey="Unternaehrer E" first="Eva" last="Unternaehrer">Eva Unternaehrer</name><affiliation wicri:level="1"><nlm:affiliation>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Douglas Mental Health University Institute, McGill University, 6875 La Salle Boulevard, Montreal, QC H4H 1R3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Douglas Mental Health University Institute, McGill University, 6875 La Salle Boulevard, Montreal, QC H4H 1R3</wicri:regionArea><wicri:noRegion>QC H4H 1R3</wicri:noRegion></affiliation></author><author><name sortKey="Bolten, Margarete" sort="Bolten, Margarete" uniqKey="Bolten M" first="Margarete" last="Bolten">Margarete Bolten</name><affiliation wicri:level="3"><nlm:affiliation>University of Basel, Child and Adolescent Psychiatric Hospital, 4058 Basel, Switzerland Ludwig-Maximilians-University Munich, Department of Psychology, 80802 Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Basel, Child and Adolescent Psychiatric Hospital, 4058 Basel, Switzerland Ludwig-Maximilians-University Munich, Department of Psychology, 80802 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Nast, Irina" sort="Nast, Irina" uniqKey="Nast I" first="Irina" last="Nast">Irina Nast</name><affiliation wicri:level="1"><nlm:affiliation>University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Zurich University of Applied Sciences, School of Health Professions, 8401 Winterthur, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Zurich University of Applied Sciences, School of Health Professions, 8401 Winterthur</wicri:regionArea><wicri:noRegion>8401 Winterthur</wicri:noRegion></affiliation></author><author><name sortKey="Staehli, Simon" sort="Staehli, Simon" uniqKey="Staehli S" first="Simon" last="Staehli">Simon Staehli</name><affiliation wicri:level="4"><nlm:affiliation>University of Trier, Institute of Psychobiology, 54296 Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Trier, Institute of Psychobiology, 54296 Trier</wicri:regionArea><wicri:noRegion>54296 Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Meyer, Andrea H" sort="Meyer, Andrea H" uniqKey="Meyer A" first="Andrea H" last="Meyer">Andrea H. Meyer</name><affiliation wicri:level="1"><nlm:affiliation>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel</wicri:regionArea><wicri:noRegion>4055 Basel</wicri:noRegion></affiliation></author><author><name sortKey="Dempster, Emma" sort="Dempster, Emma" uniqKey="Dempster E" first="Emma" last="Dempster">Emma Dempster</name><affiliation wicri:level="1"><nlm:affiliation>University of Exeter Medical School, Exeter EX1 2LU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Exeter Medical School, Exeter EX1 2LU</wicri:regionArea><wicri:noRegion>Exeter EX1 2LU</wicri:noRegion></affiliation></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Stress Medicine Trier, 54295 Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stress Medicine Trier, 54295 Trier</wicri:regionArea><wicri:noRegion>54295 Trier</wicri:noRegion><wicri:noRegion>54295 Trier</wicri:noRegion><wicri:noRegion>54295 Trier</wicri:noRegion></affiliation></author><author><name sortKey="Lieb, Roselind" sort="Lieb, Roselind" uniqKey="Lieb R" first="Roselind" last="Lieb">Roselind Lieb</name><affiliation wicri:level="1"><nlm:affiliation>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel</wicri:regionArea><wicri:noRegion>4055 Basel</wicri:noRegion></affiliation></author><author><name sortKey="Meinlschmidt, Gunther" sort="Meinlschmidt, Gunther" uniqKey="Meinlschmidt G" first="Gunther" last="Meinlschmidt">Gunther Meinlschmidt</name><affiliation wicri:level="1"><nlm:affiliation>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Ruhr-University Bochum, Faculty of Medicine, Universitaetsstrasse 150, 44801 Bochum, Germany gunther.meinlschmidt@unibas.ch.</nlm:affiliation><country wicri:rule="url">Suisse</country><wicri:regionArea>University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, 4055 Basel, Switzerland University of Basel, National Centre of Competence in Research (NCCR) Swiss Etiological Study of Adjustment and Mental Health (sesam), 4055 Basel, Switzerland Ruhr-University Bochum, Faculty of Medicine, Universitaetsstrasse 150, 44801 Bochum</wicri:regionArea><wicri:noRegion>44801 Bochum</wicri:noRegion></affiliation></author></analytic><series><title level="j">Social cognitive and affective neuroscience</title><idno type="eISSN">1749-5024</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to investigate whether maternal adversities and cortisol levels during pregnancy predict cord blood DNA methylation of the oxytocin receptor (OXTR). We collected cord blood of 39 babies born to mothers participating in a cross-sectional study (N = 100) conducted in Basel, Switzerland (2007-10). Mothers completed the Inventory of Life Events (second trimester: T2), the Edinburgh Postnatal Depression Scale (EPDS, third trimester: T3), the Trier Inventory of Chronic Stress (TICS-K, 1-3 weeks postpartum) and provided saliva samples (T2, T3) for maternal cortisol profiles, as computed by the area under the curve with respect to ground (AUCg) or increase (AUCi) for the cortisol awakening response (CAR) and for diurnal cortisol profiles (DAY). OXTR DNA methylation was quantified using Sequenom EpiTYPER. The number of stressful life events (P = 0.032), EPDS score (P = 0.007) and cortisol AUCgs at T2 (CAR: P = 0.020; DAY: P = 0.024) were negatively associated with OXTR DNA methylation. Our findings suggest that distinct prenatal adversities predict decreased DNA methylation in a gene that is relevant for childbirth, maternal behavior and wellbeing of mother and offspring. If a reduced OXTR methylation increases OXTR expression, our findings could suggest an epigenetic adaptation to an adverse early environment.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Royaume-Uni</li><li>Suisse</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Rhénanie-Palatinat</li></region><settlement><li>Munich</li><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Unternaehrer, Eva" sort="Unternaehrer, Eva" uniqKey="Unternaehrer E" first="Eva" last="Unternaehrer">Eva Unternaehrer</name></noRegion></country><country name="Allemagne"><region name="Bavière"><name sortKey="Bolten, Margarete" sort="Bolten, Margarete" uniqKey="Bolten M" first="Margarete" last="Bolten">Margarete Bolten</name></region><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name><name sortKey="Staehli, Simon" sort="Staehli, Simon" uniqKey="Staehli S" first="Simon" last="Staehli">Simon Staehli</name></country><country name="Suisse"><noRegion><name sortKey="Nast, Irina" sort="Nast, Irina" uniqKey="Nast I" first="Irina" last="Nast">Irina Nast</name></noRegion><name sortKey="Lieb, Roselind" sort="Lieb, Roselind" uniqKey="Lieb R" first="Roselind" last="Lieb">Roselind Lieb</name><name sortKey="Meinlschmidt, Gunther" sort="Meinlschmidt, Gunther" uniqKey="Meinlschmidt G" first="Gunther" last="Meinlschmidt">Gunther Meinlschmidt</name><name sortKey="Meyer, Andrea H" sort="Meyer, Andrea H" uniqKey="Meyer A" first="Andrea H" last="Meyer">Andrea H. Meyer</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Dempster, Emma" sort="Dempster, Emma" uniqKey="Dempster E" first="Emma" last="Dempster">Emma Dempster</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000120 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000120 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Rhénanie
|area= UnivTrevesV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27107296
|texte= Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27107296" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a UnivTrevesV1
| This area was generated with Dilib version V0.6.31. |  |